Blood Drug Testing

1301번

Summary: 적혈구 백혈구 임파구는 대체적으로 양호한 상태이며 혈액의 엉킴이나 산성화도 거의 없습니다 단지 혈장내 혈소판 증가되어 있는 것을 관찰할 수 있습니다 현재 드시는 Tamoxifen과도 관련이 있을 가능성이 있지만 계속 지켜볼 필요가 있습니다 특히 부모님이 간암과 뇌출혈이라는 배경이 있기 때문에 조심할 필요는 있습니다 현재까지 식사조절 물 미네랄 비타민섭취를 잘 하고 계시고 혈액건강법 비타민 미네랄 을 읽고 참고하시기를 바랍니다 네가지 책을 추천합니다 1 암과 싸우지 마라 한송 곤도마고코저2 의사와 약에 속지 않는 법 랜덤하우스중앙 미요시모토하루3 암은 혈액으로 치료한다 양문 이시하라유우미4 비타민혁명 웅징윙스 좌용진 현재 성도님께서 드시는 Tamoxifen에 대한 기초정보를 미국립암연구소 National Cancer Institute NCI 에서 정리한 내용을 올려드립니다 Tamoxifen Questions and AnswersWhat is tamoxifen Tamoxifen Nolvadex® is a medication in pill form that interferes with the activity of estrogen a hormone Tamoxifen has been used for more than 20 years to treat patients with advanced breast cancer It is used as adjuvant or additional therapy following primary treatment for early stage breast cancer In women at high risk of developing breast cancer tamoxifen reduces the chance of developing the disease Tamoxifen continues to be studied for the prevention of breast cancer It is also being studied in the treatment of several other types of cancer It is important to note that tamoxifen is also used to treat men with breast cancer How does tamoxifen work on breast cancer Estrogen promotes the growth of breast cancer cells Tamoxifen works against the effects of estrogen on these cells It is often called an anti estrogen As a treatment for breast cancer the drug slows or stops the growth of cancer cells that are present in the body As adjuvant therapy tamoxifen helps prevent the original breast cancer from returning and also helps prevent the development of new cancers in the other breast Are there other beneficial effects of tamoxifen While tamoxifen acts against the effects of estrogen in breast tissue it acts like estrogen in other tissue This means that women who take tamoxifen may derive many of the beneficial effects of menopausal estrogen replacement therapy such as lower blood cholesterol and slower bone loss osteoporosis Can tamoxifen prevent breast cancer Research has shown that when tamoxifen is used as adjuvant therapy for early stage breast cancer it reduces the risk of recurrence of the original cancer and also reduces the risk of developing new cancers in the other breast Based on these findings the National Cancer Institute NCI funded a large research study to determine the usefulness of tamoxifen in preventing breast cancer in women who have an increased risk of developing the disease This study known as the Breast Cancer Prevention Trial BCPT was conducted by the National Surgical Adjuvant Breast and Bowel Project NSABP a component of the NCI s Clinical Trials Cooperative Group Program This study found a 49 percent reduction in diagnoses of invasive breast cancer among women who took tamoxifen Women who took tamoxifen also had 50 percent fewer diagnoses of noninvasive breast tumors such as ductal or lobular carcinoma in situ However there are risks associated with tamoxifen Some are even life threatening The decision to take tamoxifen is an individual one The woman and her doctor must carefully consider the benefits and risks of therapy Women with an increased risk of developing breast cancer have the option to consider taking tamoxifen to reduce their chance of developing this disease They may also consider participating in the Study of Tamoxifen and Raloxifene see question 5 At this time there is no evidence that tamoxifen is beneficial for women who do not have an increased risk of developing breast cancer What is the Study of Tamoxifen and Raloxifene STAR and how can a woman learn more about it The Study of Tamoxifen and Raloxifene STAR is a clinical trial a research study conducted with people designed to see whether the osteoporosis drug raloxifene Evista® is more or less effective than tamoxifen in reducing the chance of developing breast cancer in women who are at an increased risk of developing the disease Raloxifene may have breast cancer risk reduction properties similar to those found in tamoxifen This study will also examine whether raloxifene has benefits over tamoxifen such as fewer side effects The STAR trial which began in June 1999 is being conducted by the NSABP It will involve about 22 000 postmenopausal women who are at least 35 years old and are at increased risk for developing breast cancer Women can learn more about the STAR trial in several ways They can call NCI s Cancer Information Service at 18004CANCER 18004226237 The number for deaf and hard of hearing callers with TTY equipment is 18003328615 Information is also available on NSABP s Web site at http www nsabp pitt edu or on the Study of Tamoxifen and Raloxifene STAR Trial Digest Page on the NCI s Web site at http www cancer gov star on the Internet What are some of the more common side effects of taking tamoxifen In general the side effects of tamoxifen are similar to some of the symptoms of menopause The most common side effects are hot flashes and vaginal discharge Some women experience irregular menstrual periods headaches fatigue nausea and or vomiting vaginal dryness or itching irritation of the skin around the vagina and skin rash As is the case with menopause not all women who take tamoxifen have these symptoms Men who take tamoxifen may experience headaches nausea and or vomiting skin rash impotence or a decrease in sexual interest Does tamoxifen cause cancers of the uterus Tamoxifen increases the risk of two types of cancer that can develop in the uterus endometrial cancer which arises in the lining of the uterus and uterine sarcoma which arises in the muscular wall of the uterus Like all cancers endometrial cancer and uterine sarcoma are potentially life threatening Women who have had a hysterectomy surgery to remove the uterus and are taking tamoxifen are not at increased risk for these cancers Endometrial cancer In the BCPT women who took tamoxifen had more than twice the chance of developing endometrial cancer compared with women who took a placebo an inactive substance that looks the same as and is administered in the same way as tamoxifen The risk of endometrial cancer in women taking tamoxifen was in the same range as or less than the risk in postmenopausal women taking single agent estrogen replacement therapy This risk is about 2 cases of endometrial cancer per 1000 women taking tamoxifen each year Most of the endometrial cancers that have occurred in women taking tamoxifen have been found in the early stages and treatment has usually been effective However for some breast cancer patients who developed endometrial cancer while taking tamoxifen the disease was life threatening Uterine sarcoma Information collected by the U S Food and Drug Administration indicates that women who have used tamoxifen for breast cancer treatment or prevention have an increased risk of developing uterine sarcoma Review of all the NSABP clinical trials using tamoxifen confirmed an increased risk of this rare cancer In the BCPT there are about 2 cases per 10 000 women taking tamoxifen each year Research to date indicates that uterine sarcomas are more likely to be diagnosed at later stages than endometrial cancers and may therefore be harder to control and more life threatening than endometrial cancer Abnormal vaginal bleeding and lower abdominal pelvic pain are symptoms of cancers of the uterus Women who are taking tamoxifen should talk with their doctor about having regular pelvic examinations and should be checked promptly if they have any abnormal vaginal bleeding or pelvic pain between scheduled exams Does tamoxifen cause blood clots or stroke Data from large treatment studies suggest that there is a small increase in the number of blood clots in women taking tamoxifen particularly in women who are receiving anticancer drugs chemotherapy along with tamoxifen The total number of women who have experienced this side effect is small The risk of having a blood clot due to tamoxifen is similar to the risk of a blood clot when taking estrogen replacement therapy Women in the BCPT who took tamoxifen also had an increased chance of developing blood clots and an increased chance of stroke Does tamoxifen cause eye problems As women age they are more likely to develop cataracts a clouding of the lens inside the eye Women taking tamoxifen appear to be at increased risk for developing cataracts Other eye problems such as corneal scarring or retinal changes have been reported in a few patients Does tamoxifen cause other types of cancer Although tamoxifen can cause liver cancer in particular strains of rats it is not known to cause liver cancer in humans It is clear however that tamoxifen can sometimes cause other liver toxicities in patients which can be severe or life threatening Doctors may order blood tests from time to time to check liver function One study suggested a possible increase in cancers of the digestive tract among women receiving tamoxifen for breast cancer Other trials including the BCPT have not shown an association between tamoxifen and these cancers Studies such as the BCPT show no increase in cancers other than uterine cancer This potential risk is being evaluated Should women taking tamoxifen avoid pregnancy Yes Tamoxifen may make premenopausal women more fertile but doctors advise women on tamoxifen to avoid pregnancy because animal studies have suggested that the use of tamoxifen in pregnancy can cause fetal harm Women who have questions about fertility birth control or pregnancy should discuss their concerns with their doctor Does tamoxifen cause a woman to begin menopause Tamoxifen does not cause a woman to begin menopause although it can cause some symptoms that are similar to those that may occur during menopause In most premenopausal women taking tamoxifen the ovaries continue to act normally and produce estrogen in the same or slightly inc 적혈구 백혈구 임파구는 대체적으로 양호한 상태이며 혈액의 엉킴이나 산성화도 거의 없습니다 단지 혈장내 혈소판 증가되어 있는 것을 관찰할 수 있습니다 현재 드시는 Tamoxifen과도 관련이 있을 가능성이 있지만 계속 지켜볼 필요가 있습니다 특히 부모님이 간암과 뇌출혈이라는 배경이 있기 때문에 조심할 필요는 있습니다 현재까지 식사조절 물 미네랄 비타민섭취를 잘 하고 계시고 혈액건강법 비타민 미네랄 을 읽고 참고하시기를 바랍니다 네가지 책을 추천합니다 1 암과 싸우지 마라 한송 곤도마고코저2 의사와 약에 속지 않는 법 랜덤하우스중앙 미요시모토하루3 암은 혈액으로 치료한다 양문 이시하라유우미4 비타민혁명 웅징윙스 좌용진 현재 성도님께서 드시는 Tamoxifen에 대한 기초정보를 미국립암연구소 National Cancer Institute NCI 에서 정리한 내용을 올려드립니다 Tamoxifen Questions and AnswersWhat is tamoxifen Tamoxifen Nolvadex® is a medication in pill form that interferes with the activity of estrogen a hormone Tamoxifen has been used for more than 20 years to treat patients with advanced breast cancer It is used as adjuvant or additional therapy following primary treatment for early stage breast cancer In women at high risk of developing breast cancer tamoxifen reduces the chance of developing the disease Tamoxifen continues to be studied for the prevention of breast cancer It is also being studied in the treatment of several other types of cancer It is important to note that tamoxifen is also used to treat men with breast cancer How does tamoxifen work on breast cancer Estrogen promotes the growth of breast cancer cells Tamoxifen works against the effects of estrogen on these cells It is often called an anti estrogen As a treatment for breast cancer the drug slows or stops the growth of cancer cells that are present in the body As adjuvant therapy tamoxifen helps prevent the original breast cancer from returning and also helps prevent the development of new cancers in the other breast Are there other beneficial effects of tamoxifen While tamoxifen acts against the effects of estrogen in breast tissue it acts like estrogen in other tissue This means that women who take tamoxifen may derive many of the beneficial effects of menopausal estrogen replacement therapy such as lower blood cholesterol and slower bone loss osteoporosis Can tamoxifen prevent breast cancer Research has shown that when tamoxifen is used as adjuvant therapy for early stage breast cancer it reduces the risk of recurrence of the original cancer and also reduces the risk of developing new cancers in the other breast Based on these findings the National Cancer Institute NCI funded a large research study to determine the usefulness of tamoxifen in preventing breast cancer in women who have an increased risk of developing the disease This study known as the Breast Cancer Prevention Trial BCPT was conducted by the National Surgical Adjuvant Breast and Bowel Project NSABP a component of the NCI s Clinical Trials Cooperative Group Program This study found a 49 percent reduction in diagnoses of invasive breast cancer among women who took tamoxifen Women who took tamoxifen also had 50 percent fewer diagnoses of noninvasive breast tumors such as ductal or lobular carcinoma in situ However there are risks associated with tamoxifen Some are even life threatening The decision to take tamoxifen is an individual one The woman and her doctor must carefully consider the benefits and risks of therapy Women with an increased risk of developing breast cancer have the option to consider taking tamoxifen to reduce their chance of developing this disease They may also consider participating in the Study of Tamoxifen and Raloxifene see question 5 At this time there is no evidence that tamoxifen is beneficial for women who do not have an increased risk of developing breast cancer What is the Study of Tamoxifen and Raloxifene STAR and how can a woman learn more about it The Study of Tamoxifen and Raloxifene STAR is a clinical trial a research study conducted with people designed to see whether the osteoporosis drug raloxifene Evista® is more or less effective than tamoxifen in reducing the chance of developing breast cancer in women who are at an increased risk of developing the disease Raloxifene may have breast cancer risk reduction properties similar to those found in tamoxifen This study will also examine whether raloxifene has benefits over tamoxifen such as fewer side effects The STAR trial which began in June 1999 is being conducted by the NSABP It will involve about 22 000 postmenopausal women who are at least 35 years old and are at increased risk for developing breast cancer Women can learn more about the STAR trial in several ways They can call NCI s Cancer Information Service at 18004CANCER 18004226237 The number for deaf and hard of hearing callers with TTY equipment is 18003328615 Information is also available on NSABP s Web site at http www nsabp pitt edu or on the Study of Tamoxifen and Raloxifene STAR Trial Digest Page on the NCI s Web site at http www cancer gov star on the Internet What are some of the more common side effects of taking tamoxifen In general the side effects of tamoxifen are similar to some of the symptoms of menopause The most common side effects are hot flashes and vaginal discharge Some women experience irregular menstrual periods headaches fatigue nausea and or vomiting vaginal dryness or itching irritation of the skin around the vagina and skin rash As is the case with menopause not all women who take tamoxifen have these symptoms Men who take tamoxifen may experience headaches nausea and or vomiting skin rash impotence or a decrease in sexual interest Does tamoxifen cause cancers of the uterus Tamoxifen increases the risk of two types of cancer that can develop in the uterus endometrial cancer which arises in the lining of the uterus and uterine sarcoma which arises in the muscular wall of the uterus Like all cancers endometrial cancer and uterine sarcoma are potentially life threatening Women who have had a hysterectomy surgery to remove the uterus and are taking tamoxifen are not at increased risk for these cancers Endometrial cancer In the BCPT women who took tamoxifen had more than twice the chance of developing endometrial cancer compared with women who took a placebo an inactive substance that looks the same as and is administered in the same way as tamoxifen The risk of endometrial cancer in women taking tamoxifen was in the same range as or less than the risk in postmenopausal women taking single agent estrogen replacement therapy This risk is about 2 cases of endometrial cancer per 1000 women taking tamoxifen each year Most of the endometrial cancers that have occurred in women taking tamoxifen have been found in the early stages and treatment has usually been effective However for some breast cancer patients who developed endometrial cancer while taking tamoxifen the disease was life threatening Uterine sarcoma Information collected by the U S Food and Drug Administration indicates that women who have used tamoxifen for breast cancer treatment or prevention have an increased risk of developing uterine sarcoma Review of all the NSABP clinical trials using tamoxifen confirmed an increased risk of this rare cancer In the BCPT there are about 2 cases per 10 000 women taking tamoxifen each year Research to date indicates that uterine sarcomas are more likely to be diagnosed at later stages than endometrial cancers and may therefore be harder to control and more life threatening than endometrial cancer Abnormal vaginal bleeding and lower abdominal pelvic pain are symptoms of cancers of the uterus Women who are taking tamoxifen should talk with their doctor about having regular pelvic examinations and should be checked promptly if they have any abnormal vaginal bleeding or pelvic pain between scheduled exams Does tamoxifen cause blood clots or stroke Data from large treatment studies suggest that there is a small increase in the number of blood clots in women taking tamoxifen particularly in women who are receiving anticancer drugs chemotherapy along with tamoxifen The total number of women who have experienced this side effect is small The risk of having a blood clot due to tamoxifen is similar to the risk of a blood clot when taking estrogen replacement therapy Women in the BCPT who took tamoxifen also had an increased chance of developing blood clots and an increased chance of stroke Does tamoxifen cause eye problems As women age they are more likely to develop cataracts a clouding of the lens inside the eye Women taking tamoxifen appear to be at increased risk for developing cataracts Other eye problems such as corneal scarring or retinal changes have been reported in a few patients Does tamoxifen cause other types of cancer Although tamoxifen can cause liver cancer in particular strains of rats it is not known to cause liver cancer in humans It is clear however that tamoxifen can sometimes cause other liver toxicities in patients which can be severe or life threatening Doctors may order blood tests from time to time to check liver function One study suggested a possible increase in cancers of the digestive tract among women receiving tamoxifen for breast cancer Other trials including the BCPT have not shown an association between tamoxifen and these cancers Studies such as the BCPT show no increase in cancers other than uterine cancer This potential risk is being evaluated Should women taking tamoxifen avoid pregnancy Yes Tamoxifen may make premenopausal women more fertile but doctors advise women on tamoxifen to avoid pregnancy because animal studies have suggested that the use of tamoxifen in pregnancy can cause fetal harm Women who have questions about fertility birth control or pregnancy should discuss their concerns with their doctor Does tamoxifen cause a woman to begin menopause Tamoxifen does not cause a woman to begin menopause although it can cause some symptoms that are similar to those that may occur during menopause In most premenopausal women taking tamoxifen the ovaries continue to act normally and produce estrogen in the same or slightly inc

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